Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yuka Kanno
PROVIDER: E-GEOD-75724 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jain Renu R Chen Yi Y Kanno Yuka Y Joyce-Shaikh Barbara B Vahedi Golnaz G Hirahara Kiyoshi K Blumenschein Wendy M WM Sukumar Selvakumar S Haines Christopher J CJ Sadekova Svetlana S McClanahan Terrill K TK McGeachy Mandy J MJ O'Shea John J JJ Cua Daniel J DJ
Immunity 20151229 1
Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain unclear. We identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the inflammatory function of Th17 cells. In contrast to thymic deletion of Blimp-1, which causes T cell development defects and spontaneous autoimmunity, peripheral deletion of this transcription factor resulted in reduced ...[more]