H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [RNA_Chondroblastoma_H3K36M_H3WT]
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Peter Lewis
PROVIDER: E-GEOD-75853 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.
Lu Chao C Jain Siddhant U SU Hoelper Dominik D Bechet Denise D Molden Rosalynn C RC Ran Leili L Murphy Devan D Venneti Sriram S Hameed Meera M Pawel Bruce R BR Wunder Jay S JS Dickson Brendan C BC Lundgren Stefan M SM Jani Krupa S KS De Jay Nicolas N Papillon-Cavanagh Simon S Andrulis Irene L IL Sawyer Sarah L SL Grynspan David D Turcotte Robert E RE Nadaf Javad J Fahiminiyah Somayyeh S Muir Tom W TW Majewski Jacek J Thompson Craig B CB Chi Ping P Garcia Benjamin A BA Allis C David CD Jabado Nada N Lewis Peter W PW
Science (New York, N.Y.) 20160501 6287
Several types of pediatric cancers reportedly contain high-frequency missense mutations in histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here we report that the H3 lysine 36-to-methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentiated sarcoma in vivo. H3K36M mutant nucleosomes inhibit the enzymatic activities of several H3K36 methyltransferases. Depleting H3K36 methyltransferases, or expressing an H3 ...[more]
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