Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression data of sciatic nerves from mice with Schwann-cell specific Sip1 deletion compared to control mice.

ABSTRACT: Schwann cell maturation is tightly controlled by a set of transcriptional regulators. We have deleted the zinc-finger transcription factor Sip1 specifically from immature Schwann cells and observed a dramatic developmental delay. In an attempt to define the developmental stage of Sip1-deficient Schwann cells, we performed microarray analysis of Schwann cell-specific mutants compared to controls at the age of 25 days (P25). Sciatic nerves of 3 mutant mice and 3 corresponding controls were isolated at the age of 25 days.

ORGANISM(S): Mus musculus

SUBMITTER: Gabriela Salinas-Riester

PROVIDER: E-GEOD-76027 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.

Quintes Susanne S Brinkmann Bastian G BG Ebert Madlen M Fröb Franziska F Kungl Theresa T Arlt Friederike A FA Tarabykin Victor V Huylebroeck Danny D Meijer Dies D Suter Ueli U Wegner Michael M Sereda Michael W MW Nave Klaus-Armin KA

Nature neuroscience 20160613 8

Schwann cell development and peripheral nerve myelination require the serial expression of transcriptional activators, such as Sox10, Oct6 (also called Scip or Pou3f1) and Krox20 (also called Egr2). Here we show that transcriptional repression, mediated by the zinc-finger protein Zeb2 (also known as Sip1), is essential for differentiation and myelination. Mice lacking Zeb2 in Schwann cells develop a severe peripheral neuropathy, caused by failure of axonal sorting and virtual absence of myelin m ...[more]

PMID: 27294512

Dataset Information

Expression data of sciatic nerves from mice with Schwann-cell specific Sip1 deletion compared to control mice.

Publications

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.

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