Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Array CGH after human challenge


ABSTRACT: Array CGH of H. pylori strain BCS100 after challenge to a new host (patients and experiment described in Graham et al., 2004, Gut, 53:1235-1243). Genomic DNA (500 ng) from the ouput from singel colony isolates obtained 15 or 90 days post innoculation were labeled with Cy5 (red) and cohybridized with 500 ng of genomic DNA from the innoculating strain BCS100 labeled with Cy3 (green). A reference experiement design type is where all samples are compared to a common reference. Computed

ORGANISM(S): Helicobacter pylori

SUBMITTER: Nina Salama 

PROVIDER: E-GEOD-7619 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection.

Salama Nina R NR   Gonzalez-Valencia Gerardo G   Deatherage Brooke B   Aviles-Jimenez Francisco F   Atherton John C JC   Graham David Y DY   Torres Javier J  

Journal of bacteriology 20070302 10


Genetic diversity of the human gastric pathogen Helicobacter pylori in an individual host has been observed; whether this diversity represents diversification of a founding strain or a mixed infection with distinct strain populations is not clear. To examine this issue, we analyzed multiple single-colony isolates from two to four separate stomach biopsies of eight adult and four pediatric patients from a high-incidence Mexican population. Eleven of the 12 patients contained isolates with identic  ...[more]

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