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Transcription profiling of human substantia nigra from postmortem brain of Parkinsons disease patients (PD)

ABSTRACT: We used microarrays to detail the global program of gene expression underlying Parkinson's disease Experiment Overall Design: Substantia nigra tissue from postmortem brain of normal and Parkinson disease patients were used for RNA extraction and hybridization on Affymetrix microarrays: 9 replicates for the controls and 16 replicates for the Parkinson's disease patients were used. Both cohorts included males and females.

ORGANISM(S): Homo sapiens

SUBMITTER: Jarlath ffrench-Mullen

PROVIDER: E-GEOD-7621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A genomic pathway approach to a complex disease: axon guidance and Parkinson disease.

Lesnick Timothy G TG Papapetropoulos Spiridon S Mash Deborah C DC Ffrench-Mullen Jarlath J Shehadeh Lina L de Andrade Mariza M Henley John R JR Rocca Walter A WA Ahlskog J Eric JE Maraganore Demetrius M DM

PLoS genetics 20070601 6

While major inroads have been made in identifying the genetic causes of rare Mendelian disorders, little progress has been made in the discovery of common gene variations that predispose to complex diseases. The single gene variants that have been shown to associate reproducibly with complex diseases typically have small effect sizes or attributable risks. However, the joint actions of common gene variants within pathways may play a major role in predisposing to complex diseases (the paradigm of ...[more]

PMID: 17571925

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Gene expression profiling of substantia nigra: a post-mortem study in Parkinson's disease and control subjects

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