Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jarlath ffrench-Mullen
PROVIDER: E-GEOD-7621 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lesnick Timothy G TG Papapetropoulos Spiridon S Mash Deborah C DC Ffrench-Mullen Jarlath J Shehadeh Lina L de Andrade Mariza M Henley John R JR Rocca Walter A WA Ahlskog J Eric JE Maraganore Demetrius M DM
PLoS genetics 20070601 6
While major inroads have been made in identifying the genetic causes of rare Mendelian disorders, little progress has been made in the discovery of common gene variations that predispose to complex diseases. The single gene variants that have been shown to associate reproducibly with complex diseases typically have small effect sizes or attributable risks. However, the joint actions of common gene variants within pathways may play a major role in predisposing to complex diseases (the paradigm of ...[more]