Dataset Information
Transcription profiling of Drosophila S2 cells transfected with Clk
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Sebastian Kadener
PROVIDER: E-GEOD-7653 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component.
Genes & development 20070619 13
Many organisms use circadian clocks to keep temporal order and anticipate daily environmental changes. In Drosophila, the master clock gene Clock promotes the transcription of several key target genes. Two of these gene products, PER and TIM, repress CLK-CYC-mediated transcription. To recognize additional direct CLK target genes, we designed a genome-wide approach and identified clockwork orange (cwo) as a new core clock component. cwo encodes a transcriptional repressor that synergizes with PER ...[more]
