Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jose Polo
PROVIDER: E-GEOD-7673 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ranuncolo Stella Maris SM Polo Jose M JM Dierov Jamil J Singer Michael M Kuo Tracy T Greally John J Green Roland R Carroll Martin M Melnick Ari A
Nature immunology 20070610 7
Antibody specificity and diversity is generated in B cells during germinal center maturation through clonal expansion while they undergo class-switch recombination and somatic hypermutation. Here we demonstrate that the transcriptional repressor Bcl-6 mediates this phenotype by directly repressing ATR in centroblasts and lymphoma cells. ATR is critical in replication and DNA damage-sensing checkpoints. Bcl-6 allowed B cells to evade ATR-mediated checkpoints and attenuated the response of the B c ...[more]