Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ramesh Ram
PROVIDER: E-GEOD-77350 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ram Ramesh R Mehta Munish M Nguyen Quang T QT Larma Irma I Boehm Bernhard O BO Pociot Flemming F Concannon Patrick P Morahan Grant G
Journal of immunology (Baltimore, Md. : 1950) 20160224 7
Genome-wide association studies have found >60 loci that confer genetic susceptibility to type 1 diabetes (T1D). Many of these are defined only by anonymous single nucleotide polymorphisms: the underlying causative genes, as well as the molecular bases by which they mediate susceptibility, are not known. Identification of how these variants affect the complex mechanisms contributing to the loss of tolerance is a challenge. In this study, we performed systematic analyses to characterize these var ...[more]