Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Benoit Bruneau
PROVIDER: E-GEOD-77576 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Luna-Zurita Luis L Stirnimann Christian U CU Glatt Sebastian S Kaynak Bogac L BL Thomas Sean S Baudin Florence F Samee Md Abul Hassan MA He Daniel D Small Eric M EM Mileikovsky Maria M Nagy Andras A Holloway Alisha K AK Pollard Katherine S KS Müller Christoph W CW Bruneau Benoit G BG
Cell 20160211 5
Transcription factors (TFs) are thought to function with partners to achieve specificity and precise quantitative outputs. In the developing heart, heterotypic TF interactions, such as between the T-box TF TBX5 and the homeodomain TF NKX2-5, have been proposed as a mechanism for human congenital heart defects. We report extensive and complex interdependent genomic occupancy of TBX5, NKX2-5, and the zinc finger TF GATA4 coordinately controlling cardiac gene expression, differentiation, and morpho ...[more]