Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nathan Salomonis
PROVIDER: E-GEOD-77849 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Meyer Sara E SE Qin Tingting T Muench David E DE Masuda Kohei K Venkatasubramanian Meenakshi M Orr Emily E Suarez Lauren L Gore Steven D SD Delwel Ruud R Paietta Elisabeth E Tallman Martin S MS Fernandez Hugo H Melnick Ari A Le Beau Michelle M MM Kogan Scott S Salomonis Nathan N Figueroa Maria E ME Grimes H Leighton HL
Cancer discovery 20160325 5
<h4>Unlabelled</h4>Cytogenetically normal acute myeloid leukemia (CN-AML) represents nearly 50% of human AML. Co-occurring mutations in the de novo DNA methyltransferase DNMT3A and the FMS related tyrosine kinase 3 (FLT3) are common in CN-AML and confer a poorer prognosis. We demonstrate that mice with Flt3-internal tandem duplication (Flt3(ITD)) and inducible deletion of Dnmt3a spontaneously develop a rapidly lethal, completely penetrant, and transplantable AML of normal karyotype. AML cells re ...[more]