Gene Expression Profile in thyroid of Transgenic Mice over-expressing the Adenosine Receptor 2a
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hortensia Mirescu
PROVIDER: E-GEOD-780 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profile in thyroid of transgenic mice overexpressing the adenosine receptor 2a.
Goffard Jean-Christophe JC Jin Ling L Mircescu Hortensia H Van Hummelen Paul P Ledent Catherine C Dumont Jacques-Emile JE Corvilain Bernard B
Molecular endocrinology (Baltimore, Md.) 20031016 1
Mutations of the TSH receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and nonautoimmune hyperthyroidism, when occurring in a germinal cell. An animal model of constitutive activation of the thyroid cAMP cascade has been obtained by generating transgenic mice expressing the adenosine receptor (Tg-A2aR) under the control of the thyroglobulin promoter. These mice develop huge goiters and die prematurely ...[more]
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