Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Wei Chen
PROVIDER: E-GEOD-78241 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Xi X Hou Jingyi J Quedenau Claudia C Chen Wei W
Molecular systems biology 20160718 7
Transcription initiated at alternative sites can produce mRNA isoforms with different 5'UTRs, which are potentially subjected to differential translational regulation. However, the prevalence of such isoform-specific translational control across mammalian genomes is currently unknown. By combining polysome profiling with high-throughput mRNA 5' end sequencing, we directly measured the translational status of mRNA isoforms with distinct start sites. Among 9,951 genes expressed in mouse fibroblast ...[more]