Transcription profiling of human normal and transformed buccal keratinocytes
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Roland Grafström
PROVIDER: E-GEOD-7862 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma.
Staab Claudia A CA Ceder Rebecca R Jägerbrink Theres T Nilsson Jan-Anders JA Roberg Karin K Jörnvall Hans H Höög Jan-Olov JO Grafström Roland C RC
Journal of proteome research 20070815 9
Normal and two transformed buccal keratinocyte lines were cultured under a standardized condition to explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein levels. An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-scale transcript data to low-abundance transcriptional regulators. The analysis identified previously proposed and suggested novel protein biomarkers, gene ontology categories, molecular networks, and ...[more]
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