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Expression data from the mouse ES cell-derived differentiated cells treated with or without MPA

ABSTRACT: Mycophenolic acid (MPA), effectively promoted ES cell pancreatic differentiation with a concomitant reduction of neuronal cells. The targets of MPA were investigated by microarray analysis of cells treated on day 5 with MPA and harvested on day 6 and 8. Cells were harvested for RNA extraction and hybridization on Affymetrix microarrays. We performed gene expression profiles of differentiated mouse ES cells treated with or without 2 microM MPA at day5, 6, and 8

ORGANISM(S): Mus musculus

SUBMITTER: nobuaki shiraki

PROVIDER: E-GEOD-78797 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from the mouse ES cell-derived differentiated cells treated with or without MPA

Project description:Mycophenolic acid (MPA), effectively promoted ES cell pancreatic differentiation with a concomitant reduction of neuronal cells. The targets of MPA were investigated by microarray analysis of cells treated on day 5 with MPA and harvested on day 6 and 8.

2016-03-02 | GSE78797 | GEO

Gene expression analysis of Photobacterium profundum DB110 and TW30 toxR mutant strain at 0.1 MPa and 28 MPa

Project description:Here we report the massively parallel cDNA sequencing (RNA-seq) analysis performed using high throughput sequencing of wild type (DB110) and toxR (TW30) mutant strains of the deep-sea bacterium Photobacterium profundum. ToxR is a transmembrane DNA-binding protein first discovered in Vibrio cholerae and able to regulate numerous genes involved in virulence. In P. profundum the abundance and activity of the same protein is influenced by hydrostatic pressure and is able to regulate genes in a pressure-dependent manner. To better characterize the ToxR regulon, we have compared the genes differentially expressed in response to pressure changes with those whose expression is altered between wild type and toxR mutant strains. Four samples were analyzed: DB110 strain grown at 0.1 MPa, DB110 strain grown at 28 MPa, TW30 strain grown at 0.1 MPa, TW30 strain grown at 28 MPa. Two independent coltures (replicates) were grown for each sample, RNA was extracted from each replicate and RNAs from the two replicates were pooled together to reduce biological variability. No replicates were included in experimental design.

2012-12-22 | E-GEOD-38259 | biostudies-arrayexpress

A broad array of anticancer activities of the immunosuppressive drug mycophenolic acid (MPA) is suggested by pathway analyses of gene expression and validated by proteomic and functional assays

Project description:Gene expression microarray was performed to assess the global changes coupled to targeted validation of proteomic profiling to reveal the broad anticancer activities of the immunosuppressive drug Mycophenolic acid (MPA) and elucidate the molecular mechanisms underlying these activities. We conducted gene expression microarray experiments on AGS cancers cells treated with Mycophenolic acid (MPA). A concentration of 2ug/ml was selected to treat AGS cells and the treated cells were harvested at 0, 12, 24, 48 and 72 hours of culture with the drug. Gene expression analyses were carried out using Illumina Human 12 Beadchips.

2013-10-28 | E-GEOD-46671 | biostudies-arrayexpress

A broad array of anticancer activities of the immunosuppressive drug mycophenolic acid (MPA) is suggested by pathway analyses of gene expression and validated by proteomic and functional assays

2013-10-28 | GSE46671 | GEO

Microarray gene expression analyses of DMBA/MPA induced mammary tumors

Project description:Exploration of the transcriptome of DMBA/MPA induced mammary tumors including murine subtyping

2019-02-28 | E-MTAB-7507 | biostudies-arrayexpress

Genome wide RNA expression profiles of endometrial stromal cells stimulated by cAMP, cAMP+MPA, MPA and E2+MPA.

Project description:To know the differences of decidualization induced by different stimuli, we compared the mRNA expression profiles of decidualized ESCs stimulated by cAMP or cAMP+MPA for 4 days, or by MPA or E2+MPA for 14 days.

2024-04-10 | GSE235151 | GEO

Transcription profiling of Phytobacterium profundum SS9 strain cells grown at two different pressure conditions 0.1 MPa and at 28 MPa

Project description:P. profundum SS9 strain cells were grown at two different pressure conditions 0.1 MPa and at 28 MPa. RNA extracted from the two different cultures was labelled with Cy5 and Cy3 and competitively hybridized on the same slide.

2005-07-28 | E-MEXP-210 | biostudies-arrayexpress

Genome wide RNA expression profiles of endometrial stromal cells stimulated by cAMP, cAMP+MPA, MPA and E2+MPA.

Project description:Genome wide RNA expression profiles of endometrial stromal cells stimulated by cAMP, cAMP+MPA, MPA and E2+MPA.

| PRJNA984674 | ENA

Transcription profiling of Photobacterium profundum SS9 strain cells grown at two different pressure conditions 45 MPa and at 28 MPa

Project description:P. profundum SS9 strain cells were grown at two different pressure conditions 45 MPa and at 28 MPa. RNA extracted from the two different cultures was labelled with Cy5 and Cy3 and competitively hybridized on the same slide.

2006-05-24 | E-MEXP-374 | biostudies-arrayexpress

Recovery from 30 MPa 25 C

Project description:Hydrostatic pressure is one of the physical factors affecting cellular physiology. Hydrostatic pressure of a few hundred MPa decreases the viability of yeast cells, and pressure of a few tens MPa decreases the growth rate. To understand the effect of hydrostatic pressure, we employed yeast, Saccharomyces cerevisiae, DNA microarrays and analyzed genome-wide mRNA expression profiles under hydrostatic pressures. In this experiment, we selected a hydrostatic pressure of 30 MPa at 25 degrees C because yeast cells are able to grow with this condition. Keywords: stress response

2007-11-01 | GSE9403 | GEO

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