Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Martin Turner
PROVIDER: E-GEOD-79179 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vogel Katharina U KU Bell Lewis S LS Galloway Alison A Ahlfors Helena H Turner Martin M
Journal of immunology (Baltimore, Md. : 1950) 20160826 7
The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly to enforce the β-selection checkpoint during thymopoiesis, yet their molecular targets remain largely unknown. In this study, we identify these targets on a genome-wide scale in primary mouse thymocytes and show that Zfp36l1/l2 regulate DNA damage response and cell cycle transcripts to ensure proper β-selection. Double-negative 3 thymocytes lacking Zfp36l1/l2 share a gene expression profile with postselected double-negative 3b cells de ...[more]