Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome profiles derived from parallel venipuncture, dried blood spot (DBS), and saliva samples


ABSTRACT: Comparison of transcript abundance estimates derived from DBS vs saliva vs gold standard peripheral blood mononuclear cell (PBMC) samples. Gene expression profiling was conducted using parallel collection and assay of venipuncture blood samples (PBMC), DBS samples, and saliva. Data come from 58 community dwelling adults recruited from the Los Angeles metropolitan area. Analyzed data include basic demographic characteristics (age, sex, race/ethnicity) and body mass index (BMI) as well as RNA indicators of major leukocyte subset prevalence (i.e., estimated abundance of mRNA for CD3, CD4, CD8, CD19, FCGR3A/CD16, NCAM1/CD56, and CD14; all provided here as log2-transformed values of normalized gene expression data). Categorial variables were coded 0=no/absent and 1=yes/present.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Cole 

PROVIDER: E-GEOD-79269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Psychological resilience and the gene regulatory impact of posttraumatic stress in Nepali child soldiers.

Kohrt Brandon A BA   Worthman Carol M CM   Adhikari Ramesh P RP   Luitel Nagendra P NP   Arevalo Jesusa M G JM   Ma Jeffrey J   McCreath Heather H   Seeman Teresa E TE   Crimmins Eileen M EM   Cole Steven W SW  

Proceedings of the National Academy of Sciences of the United States of America 20160711 29


Adverse social conditions in early life have been linked to increased expression of proinflammatory genes and reduced expression of antiviral genes in circulating immune cells-the conserved transcriptional response to adversity (CTRA). However, it remains unclear whether such effects are specific to the Western, educated, industrialized, rich, and democratic (WEIRD) cultural environments in which previous research has been conducted. To assess the roles of early adversity and individual psycholo  ...[more]

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