The Glioma-Infiltrating T Cell Receptor Repertoire

ABSTRACT: While immune signaling has emerged as a defining feature of the glioma microenvironment, local selection of responding T cells and their anti-tumor potential as a population are difficult to measure directly in patients. High-throughput sequencing of T cell receptor repertoires (TCRseq) provides a population-wide statistical description of how T cells respond to disease. Here, we define new immunophenotypes in glioma based on TCRseq and RNA-Seq of tumor tissue, non-neoplastic brain tissue, and peripheral blood from patients. Using information theory, we characterize antigen-driven selection in glioma and its relationship with the expression of distinct immune-functional pathways in the tumor microenvironment. Finally, we identify a strong relationship between usage of certain TCR in perip

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Sims 

PROVIDER: E-GEOD-79338 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress