Microarray analysis of CD14+ CD163high CD160high cells in human intestinal lamina propria

ABSTRACT: Several innate immune cell subsets have recently been identified to maintain gut homeostasis in both human and mice. Among these subsets, CX3CR1high CD11b+ CD11c+ cells contribute to intestinal tolerance through various mechanisms in mice. However, whether tolerogenic innate myeloid cells are present in the human intestine is not clearly defined. In this manuscript, we identified an intestinal myeloid cell subset possessing tolerogenic ability. HLA-DRhigh CD14+ CD163high cells in the human colon were divided into two subsets based on CD160 expression: CD163high CD160high and CD163high CD160low cells. Both cell subsets exhibited high levels of IL-10 production and high phagocytic activities. CD163high CD160high cells suppressed effector CD4+ T cell proliferation by a Foxp3+ Treg cell induct

ORGANISM(S): Homo sapiens

SUBMITTER: Daisuke Okuzaki 

PROVIDER: E-GEOD-79627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress