Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human newborn cord blood born to arsenic exposed mothers reveals activation of inflammation/NF-kappaB signalling


ABSTRACT: We are investigating the transcriptional response of newborns in response to prenatal arsenic exposure; We used microarrays to detail the global programme of gene expression response due to prenatal arsenic exposure Experiment Overall Design: cord blood was collected at birth from infants whose mothers were exposed or unexposed to arsenic

ORGANISM(S): Homo sapiens

SUBMITTER: Rebecca Fry 

PROVIDER: E-GEOD-7967 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


The long-term health outcome of prenatal exposure to arsenic has been associated with increased mortality in human populations. In this study, the extent to which maternal arsenic exposure impacts gene expression in the newborn was addressed. We monitored gene expression profiles in a population of newborns whose mothers experienced varying levels of arsenic exposure during pregnancy. Through the application of machine learning-based two-class prediction algorithms, we identified expression sign  ...[more]

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