Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: You-Qiang Su
PROVIDER: E-GEOD-79862 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Guo Jing J Shi Lanying L Gong Xuhong X Jiang Mengjie M Yin Yaoxue Y Zhang Xiaoyun X Yin Hong H Li Hui H Emori Chihiro C Sugiura Koji K Eppig John J JJ Su You-Qiang YQ
Journal of cell science 20160629 16
Communication between oocytes and their companion somatic cells promotes the healthy development of ovarian follicles, which is crucial for producing oocytes that can be fertilized and are competent to support embryogenesis. However, how oocyte-derived signaling regulates these essential processes remains largely undefined. Here, we demonstrate that oocyte-derived paracrine factors, particularly GDF9 and GDF9-BMP15 heterodimer, promote the development and survival of cumulus-cell-oocyte complexe ...[more]