Genome-wide distribution of UHRF2 and ZNF618 in 293T cells.
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lin-Yu Lu
PROVIDER: E-GEOD-80037 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.
Liu Yidan Y Zhang Bin B Kuang Henry H Korakavi Gautam G Lu Lin-Yu LY Yu Xiaochun X
The Journal of biological chemistry 20160427 26
5-Hydroxymethylcytosine (5hmC) is an epigenetic modification that is generated by ten-eleven translocation (TET) protein-mediated oxidation of 5-methylcytosine (5mC). 5hmC is associated with transcription regulation and is decreased in many cancers including melanoma. Accumulating evidence has suggested that 5hmC is functionally distinct from 5mC. Ubiquitin-like with PHD and ring finger domains 2 (UHRF2) is the first known specific 5hmC reader that has higher affinity to 5hmC than 5mC, suggestin ...[more]
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