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Pervasive effects of aging on gene expression in wild wolves

ABSTRACT: We sequenced total RNA from whole blood samples of 27 wild gray wolves from Yellowstone National Park. Gene expression level analysis of both male and female wolves, ranging from ages 0.8-8.8 years.

ORGANISM(S): Canis lupus

SUBMITTER: Rachel Johnston

PROVIDER: E-GEOD-80440 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pervasive Effects of Aging on Gene Expression in Wild Wolves.

Charruau Pauline P Johnston Rachel A RA Stahler Daniel R DR Lea Amanda A Snyder-Mackler Noah N Smith Douglas W DW vonHoldt Bridgett M BM Cole Steven W SW Tung Jenny J Wayne Robert K RK

Molecular biology and evolution 20160415 8

Gene expression levels change as an individual ages and responds to environmental conditions. With the exception of humans, such patterns have principally been studied under controlled conditions, overlooking the array of developmental and environmental influences that organisms encounter under conditions in which natural selection operates. We used high-throughput RNA sequencing (RNA-Seq) of whole blood to assess the relative impacts of social status, age, disease, and sex on gene expression le ...[more]

PMID: 27189566

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