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DNA methylation profiling of polycystic ovarian syndrome (PCOS)

ABSTRACT: Genome-wide DNA methylation analysis on PCOS using Illumina HumanMethylation 450K BeadChips in 30 PCOS patients and 30 healthy controls Case-control design

ORGANISM(S): Homo sapiens

SUBMITTER: Qihua Tan

PROVIDER: E-GEOD-80468 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women.

Li Shuxia S Zhu Dongyi D Duan Hongmei H Ren Anran A Glintborg Dorte D Andersen Marianne M Skov Vibe V Thomassen Mads M Kruse Torben T Tan Qihua Q

Oncotarget 20170301 13

As a universally common endocrinopathy in women of reproductive age, the polycystic ovarian syndrome is characterized by composite clinical phenotypes reflecting the contributions of reproductive impact of ovarian dysfunction and metabolic abnormalities with widely varying symptoms resulting from interference of the genome with the environment through integrative biological mechanisms including epigenetics. We have performed a genome-wide DNA methylation analysis on polycystic ovarian syndrome a ...[more]

PMID: 27192117

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