Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Messenger RNA expression after MK2206/DMSO treatment of T47D cells

ABSTRACT: We performed RNA-seq in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We show that a group of transcripts is differentailly expressed after AKT inhibition. Comparison of mRNA levels using RNA-seq after AKT inhibition vs vehicle

ORGANISM(S): Homo sapiens

SUBMITTER: Koen Dreijerink 

PROVIDER: E-GEOD-80591 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Post-translational histone H3 modifications regulate transcriptional competence. The mechanisms by which the epigenome is regulated in response to oncogenic signaling remain unclear. Here we show that H3K4me3 is increased in breast tumors driven by an activated PIK3CA allele and that inhibition of PI3K/AKT signaling reduces promoter-associated H3K4me3 in human breast cancer cells. We show that the H3K4 demethylase KDM5A is an AKT target and that phosphorylation of KDM5A regulates its nuclear loc  ...[more]

Similar Datasets

Genomics Genome-wide H3K4me3 after MK2206/DMSO treatment of T47D cells
2016-06-14 | E-GEOD-80592 | biostudies-arrayexpress
Genomics Genome-wide KDM5A occupancy after MK2206/DMSO treatment of T47D cells
2016-06-14 | E-GEOD-80593 | biostudies-arrayexpress
Transcriptomics Messenger RNA expression after MK2206/DMSO treatment of T47D cells
2016-06-14 | GSE80591 | GEO
Genomics Genome-wide H3K4me3 after MK2206/DMSO treatment of T47D cells
2016-06-14 | GSE80592 | GEO
Genomics Genome-wide KDM5A occupancy after MK2206/DMSO treatment of T47D cells
2016-06-14 | GSE80593 | GEO
Genomics RNA-seq analysis of AKTi MK2206 resistant BT474 and T47D cells
| PRJNA484709 | ENA
Clinical Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma
| 2099453 | ecrin-mdr-crc
Transcriptomics Akt inhibitor MK2206 prevents influenza A(H1N1)pdm09 virus infection in vitro
2014-01-23 | GSE54293 | GEO
Clinical Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer
| 2099584 | ecrin-mdr-crc
Transcriptomics Akt inhibitor MK2206 prevents influenza A(H1N1)pdm09 virus infection in vitro
2014-01-23 | E-GEOD-54293 | biostudies-arrayexpress