Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

A nested case-control study to investigate drivers for metastatic disease in breast cancer (QC substudy)


ABSTRACT: This is a quality control (QC) substudy of GSE48091. The QC substudy comprises gene-expression profiling of re-extracted tumor RNA for a subset of the tumours in the full study. As background, a population-based cohort study of metastatic breast cancer patients was first designed. Thereafter, a case-control study nested in the corresponding population-based cohort of primary breast cancer patients was designed by selecting distant metastasis-free controls to each case. Tumor RNA was extracted in the same order. All RNA was profiled on microarrays in randomized order. For quality control, RNA was also re-extracted (new tumor piece) in a randomized order for randomly selected cases-controls sets and profiled with the rest. Keywords: Expression profiling by array The nested case-control study included 768 study subjects corresponding to 623 primary tumor samples. This QC substudy comprises 97 of the study subjects (all different primary tumor samples). Details concerning case-control status are given in the samples section. This Series includes a re-analysis of 97 samples from GSE48091. The file "full_data_matrix.txt" includes the re-normalized values for the 97 samples from GSE48091 and the normalized values for the 97 new samples from the same patients that were analyzed together.

ORGANISM(S): Homo sapiens

SUBMITTER: John Lövrot 

PROVIDER: E-GEOD-81954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2016-05-28 | GSE81954 | GEO
2014-11-03 | E-GEOD-48091 | biostudies-arrayexpress
| PRJNA323489 | ENA
2012-02-23 | GSE30758 | GEO
2017-04-01 | GSE67530 | GEO
| PRJEB32479 | ENA
2012-02-20 | E-GEOD-30760 | biostudies-arrayexpress
2015-07-08 | GSE48091 | GEO
| PRJNA434312 | ENA
| PRJNA208904 | ENA