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Chemokine and receptor expression by WT and LIGHT-expressing tumor tissues

ABSTRACT: A study to compare chemokine and receptor expression by LIGHT-positive vs. negative tumor tissue

ORGANISM(S): Mus musculus

SUBMITTER: Ping Yu

PROVIDER: E-GEOD-836 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Priming of naive T cells inside tumors leads to eradication of established tumors.

Yu Ping P Lee Youjin Y Liu Wenhua W Chin Robert K RK Wang Jing J Wang Yang Y Schietinger Andrea A Philip Mary M Schreiber Hans H Fu Yang-Xin YX

Nature immunology 20040104 2

The tumor barrier comprised of nonantigenic stromal cells may contribute to the failure of tumor rejection. The tumor-necrosis factor superfamily member LIGHT (also known as TNFSF-14) is a ligand of stromal cell-expressed lymphotoxin-beta receptor and T cell-expressed herpes viral entry mediator (HVEM). Here we show that forced expression of LIGHT in the tumor environment induces a massive infiltration of naive T lymphocytes that correlates with an upregulation of both chemokine production and e ...[more]

PMID: 14704792

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