Unknown,Transcriptomics,Genomics,Proteomics

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Effect of GDF11 on RANKL-induced osteoclastogenesis


ABSTRACT: GDF11 treatment leads to bone loss in mice and strongly stimulates RANKL-induced osteoclastogenesis of bone marrow-“derived macrophages (BMMs) in vitro. We used microarrays to identified distinct classes of up-regulated genes in BMMs after GDF11 treatment. Mouse BMMs were treated with or without GDF11 for RNA extraction and and hybridization on Affymetrix microarrays

ORGANISM(S): Mus musculus

SUBMITTER: Quan Yuan 

PROVIDER: E-GEOD-84609 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation.

Liu Weiqing W   Zhou Liyan L   Zhou Chenchen C   Zhang Shiwen S   Jing Junjun J   Xie Liang L   Sun Ningyuan N   Duan Xiaobo X   Jing Wei W   Liang Xing X   Zhao Hu H   Ye Ling L   Chen Qianming Q   Yuan Quan Q  

Nature communications 20160922


Osteoporosis is an age-related disease that affects millions of people. Growth differentiation factor 11 (GDF11) is a secreted member of the transforming growth factor beta (TGF-β) superfamily. Deletion of Gdf11 has been shown to result in a skeletal anterior-posterior patterning disorder. Here we show a role for GDF11 in bone remodelling. GDF11 treatment leads to bone loss in both young and aged mice. GDF11 inhibits osteoblast differentiation and also stimulates RANKL-induced osteoclastogenesis  ...[more]

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