Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Quan Yuan
PROVIDER: E-GEOD-84609 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Liu Weiqing W Zhou Liyan L Zhou Chenchen C Zhang Shiwen S Jing Junjun J Xie Liang L Sun Ningyuan N Duan Xiaobo X Jing Wei W Liang Xing X Zhao Hu H Ye Ling L Chen Qianming Q Yuan Quan Q
Nature communications 20160922
Osteoporosis is an age-related disease that affects millions of people. Growth differentiation factor 11 (GDF11) is a secreted member of the transforming growth factor beta (TGF-β) superfamily. Deletion of Gdf11 has been shown to result in a skeletal anterior-posterior patterning disorder. Here we show a role for GDF11 in bone remodelling. GDF11 treatment leads to bone loss in both young and aged mice. GDF11 inhibits osteoblast differentiation and also stimulates RANKL-induced osteoclastogenesis ...[more]