Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ivy Moffat
PROVIDER: E-GEOD-8474 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Moffat Ivy D ID Boutros Paul C PC Celius Trine T Lindén Jere J Pohjanvirta Raimo R Okey Allan B AB
Toxicological sciences : an official journal of the Society of Toxicology 20070813 2
Dioxin-like chemicals are well known for their ability to upregulate expression of numerous genes via the AH receptor (AHR). However, recent transcriptomic analyses in several laboratories indicate that dioxin-like chemicals or AHR genotype itself also can downregulate levels of mRNAs encoded by numerous genes. The mechanism responsible for such downregulation is unknown. We hypothesized that microRNAs (miRNAs), which have emerged as powerful negative regulators of mRNA levels in several systems ...[more]