Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human MCF-7 breast cancer cells treated with E2, ICI 182,789 (ICI), Raloxifene (Ral), and/or trans-hydroxytamoxifen (TOT)


ABSTRACT: MCF-7 breast cancer cells were treated with E2, ICI 182,789 (ICI), Raloxifene (Ral), and/or trans-hydroxytamoxifen (TOT) for 8 or 48 h. Duplicate samples are labeled set A or set B.

ORGANISM(S): Homo sapiens

SUBMITTER: Jonna Frasor 

PROVIDER: E-GEOD-848 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells.

Frasor Jonna J   Stossi Fabio F   Danes Jeanne M JM   Komm Barry B   Lyttle C Richard CR   Katzenellenbogen Benita S BS  

Cancer research 20040201 4


Selective estrogen receptor modulators (SERMs) such as tamoxifen are effective in the treatment of many estrogen receptor-positive breast cancers and have also proven to be effective in the prevention of breast cancer in women at high risk for the disease. The comparative abilities of tamoxifen versus raloxifene in breast cancer prevention are currently being compared in the Study of Tamoxifen and Raloxifene trial. To better understand the actions of these compounds in breast cancer, we have exa  ...[more]

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