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Transcription profiling of rat AFTER IN vivo administration OF Gamendazole AND Lonidamine

ABSTRACT: rat testis time changes; Experimental details are found at Tash et al, Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP-90, eEF1A, and stimulates IL-1 transcription in Sertoli cells, Biol. Reprod. (2007) under review Experiment Overall Design: Adult male rats administered single ip dose of 6mg/kg Gamendazole or 25 mg/kg lonidamine or vehicle control (buffered DMSO) - testes harvested at 0 4 12 and 24 hr - 3 chips used for each time point

ORGANISM(S): Rattus rattus

SUBMITTER: Joseph Tash

PROVIDER: E-GEOD-8485 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose.

Tash Joseph S JS Attardi Barbara B Hild Sheri A SA Chakrasali Ramappa R Jakkaraj Sudhakar R SR Georg Gunda I GI

Biology of reproduction 20080123 6

Women have historically been the focus for development of new contraceptive methods. The National Institutes of Health, World Health Organization, and Institute of Medicine have stressed the need to develop nonhormonal, nonsteroidal male contraceptive agents. We report results from initial dose-ranging studies of a new indazole carboxylic acid analogue, gamendazole. An infertility rate of 100% was achieved in seven out of seven proven-fertile male rats 3 wk after a single oral dose of 6 mg/kg of ...[more]

PMID: 18218612

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In vivo administration of Gamendazole and Lonidamine

Project description:rat testis time changes Experimental details are found at Tash et al, Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP-90, eEF1A, and stimulates IL-1 transcription in Sertoli cells, Biol. Reprod. (2007) under review Keywords: time course

2008-01-24 | GSE8485 | GEO

Evalutation of DEGs by RNA-seq in thiaclopride exposed murine testis

Project description:Environmental factors such as pesticides could affect developmental processes and cause phenotypic changes. In this project we study whether the exposure to neonicotinoid pesticide, thiaclopride, during embryonic development, could cause gene expression deregulation in outbred Swiss mice. Mice were treated during embryonic development at dose 6mg/kg body weight/day. New-borns were grown until 35 days-old. RNA was extracted from testes of three different mice for each condition (control vs exposed) and stranded libraries were prepared.

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