Gene Expression Profiling in the Lungs of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer

ABSTRACT: COPD is a common and disabling lung disease for which very few therapeutic options are currently available. We reasoned that global gene expression profiling of COPD lungs could reveal previously unidentified disease pathways for potential therapeutic interventions. Forty-eight human lung samples were obtained from lungs or lobes resected for small peripheral lung lesions (5 non-smokers, 21 GOLD 0, 9 GOLD 1, 10 GOLD 2 and 3 GOLD 3 patients). mRNA from the specimens was profiled using Agilent’s Functional ID v2.0 array which contains 23,720 sequences. Quantitative morphometric analysis of the specimens revealed that the samples contained a variable proportion of airways, blood vessels and parenchyma. Incorporating these data into a model relating gene expression to % predicted forced expira

ORGANISM(S): Homo sapiens

SUBMITTER: serguei stepaniants 

PROVIDER: E-GEOD-8500 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress