Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kazuya Iwamoto
PROVIDER: E-GEOD-8567 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20071212 12
<h4>Background</h4>In single-cell human genome analysis using whole-genome amplified product, a strong amplification bias involving allele dropout and preferential amplification hampers the quality of results. Using an oligonucleotide single nucleotide polymorphism (SNP) array, we systematically examined the nature of this amplification bias, including frequency, degree, and preference for genomic location, and we assessed the effects of this amplification bias on subsequent genotype and chromos ...[more]