Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human peripheral mononuclear blood cells taken from survivors of psychological trauma a few hours after the trauma and four months later

ABSTRACT: PTSD - Posttraumatic stress disorder. 33 samples taken from PMBCs of survivors of psychological trauma, in two time points: in ER, few hours after the truma, and four months later. Some of the patients devepled chronic PTSD (17 samples) and others recovered and set to be the Control group (16 samples). This is the normalized active genes: 4512 probes from U95A chip. The raw data is available in series GSE845. Samples are labeled with 3 tags: P/C for PTSD or Control, ER/M4 - for time point of sample, D/ND for Decrement or Non-decrement symptoms over time. (e.g. sample 23C-M4-D-Norm was taken 4 months after trauma from patient 23 which belongs to the control group and showed decrease in symptoms) . Samples include the expression value, the GeneBank accession number and Affymetrix indication of valid calls.

ORGANISM(S): Homo sapiens

DISEASE(S): reference

SUBMITTER: Noa Shefi 

PROVIDER: E-GEOD-860 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors.

Segman R H RH   Shefi N N   Goltser-Dubner T T   Friedman N N   Kaminski N N   Shalev A Y AY  

Molecular psychiatry 20050501 5

Trauma survivors show marked differences in the severity and persistence of post-traumatic stress disorder (PTSD) symptoms. Early symptoms subside in most, but persist as acute and chronic PTSD in a significant minority. The underlying molecular mechanisms or outcome predictors determining these differences are not known. Molecular markers for identifying any mental disorder are currently lacking. Gene expression profiling during the triggering and development of PTSD may be informative of its o  ...[more]

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