Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of testicular seminoma tumour stages (pT1, pT2, pT3) and 3 normal testes


ABSTRACT: Gene expression patterns of testicular seminoma were analysed applying oligonucleotide microarrays in 40 specimens of different tumour stages (pT1, pT2, pT3) and in 3 normal testes. Experiment Overall Design: A total of 40 pure seminoma including 22 samples of tumour stage 1 (pT1), 14 samples of tumour stage 2 (pT2) and 4 of tumour stage 3 (pT3) as well as three normal testicular samples of high-quality mRNA were used for microarray analyses.

ORGANISM(S): Homo sapiens

DISEASE(S): testicular seminoma

SUBMITTER: Ludger Klein-Hitpass 

PROVIDER: E-GEOD-8607 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4.

Gashaw I I   Grümmer R R   Klein-Hitpass L L   Dushaj O O   Bergmann M M   Brehm R R   Grobholz R R   Kliesch S S   Neuvians T P TP   Schmid K W KW   von Ostau C C   Winterhager E E  

Cellular and molecular life sciences : CMLS 20051001 19-20


Gene expression patterns of testicular seminoma were analysed applying oligonucleotide microarrays in 40 specimens of different tumour stages (pT1, pT2, pT3) and in normal testes. Transcripts of maternally expressed 3 transcripts were expressed in seminoma without correlation with delta-like 1 homologue expression indicating an impaired imprinting status in seminoma. Interestingly, the transcripts of bromodomain-containing 2 and nuclear autoantigenic sperm protein associated with spermatogenesis  ...[more]

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