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Transcriptional pathways associated with skeletal muscle disuse atrophy in humans

ABSTRACT: Disuse atrophy is a common clinical phenomenon which significantly impacts muscle function and activities of daily living. In this study, we did expression profiling to identify transcriptional pathways associated with muscle remodeling in a clinical model of disuse. Keywords: Differentiation design 28 Skeletal muscle biopsies from the medial gastrocnemius in patients with an ankle fracture (4 patients, 8 profiles) and from healthy volunteers (2 subjects, 4 profiles) subjected to 4-11 days of mobilization, as well as from the non-immobilized contralateral legs (16 profiles).

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Hoffman

PROVIDER: E-GEOD-8872 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional pathways associated with skeletal muscle disuse atrophy in humans.

Chen Yi-Wen YW Gregory Chris M CM Scarborough Mark T MT Shi Rongye R Walter Glenn A GA Vandenborne Krista K

Physiological genomics 20070905 3

Disuse atrophy is a common clinical phenomenon that significantly impacts muscle function and activities of daily living. The purpose of this study was to implement genome-wide expression profiling to identify transcriptional pathways associated with muscle remodeling in a clinical model of disuse. Skeletal muscle biopsies were acquired from the medial gastrocnemius in patients with an ankle fracture and from healthy volunteers subjected to 4-11 days of cast immobilization. We identified 277 mis ...[more]

PMID: 17804603

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