Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

A Gene Expression-Based Risk Stratification Model for Newly Diagnosed Multiple Myeloma


ABSTRACT: We recently defined a gene expression-based signature of high-risk multiple myeloma; this predictive signature was developed with and independently validated for newly diagnosed patients treated with high dose therapy and stem cell rescue. Here we use Phase 3 clinical trial data to show that this signature also predicts short survival in relapsed disease treated with single agent bortezomib or high dose dexamethasone. In addition, a survival signature derived with relapsed myeloma samples identified newly diagnosed patients with short survival. Taken together these data suggest that a similar biology underlies poor outcome in both newly diagnosed and relapsed myeloma and provide strong evidence that the high-risk signature is a powerful tool to identify patients who are candidates for new therapeutic regimens. Keywords: Model validation See above (Series_summary)

ORGANISM(S): Homo sapiens

SUBMITTER: Yiming Zhou 

PROVIDER: E-GEOD-8991 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2011-08-20 | GSE8991 | GEO
2008-10-18 | E-GEOD-8546 | biostudies-arrayexpress
2016-04-05 | E-MTAB-3660 | biostudies-arrayexpress
2023-03-31 | E-MTAB-12760 | biostudies-arrayexpress
2011-01-26 | E-GEOD-26849 | biostudies-arrayexpress
2011-01-20 | E-GEOD-26760 | biostudies-arrayexpress
2008-06-13 | E-GEOD-2658 | biostudies-arrayexpress
2008-08-04 | GSE8546 | GEO
2013-04-03 | E-GEOD-43860 | biostudies-arrayexpress
2023-06-16 | GSE234807 | GEO