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Transcription profiling of mouse C57Bl/6 or gp91phox-/- animals following exposure to conidia or polystyrene beads

ABSTRACT: The response of AM transcription to exposure to conidia is expected to provide information about the mechanism by which these cells prevent conidial germination and therefore invasive aspergillosis. Experiment Overall Design: Conidia from A. fumigatus or polystyrene beads were instilled into lungs of C57Bl/6 or gp91phox-/- mice to test the response of AM in a normal and immune compromised host to determine if different responses contributed to increased susceptibility of invasive aspergillosis. Following in vivo incubation for 0, 2, or 4 hours, AM RNA was collected and prepared for hybridization to mouse Affymetrix GeneChip arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Kate McInnerney

PROVIDER: E-GEOD-8997 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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