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UV irradiation of human melanocytes

ABSTRACT: Target genes of ultraviolet stress response in cutaneous melanocytes, potentially associated with solar induced melanocarcinogenesis, were characterized by cDNA microarray technology. In cultured normal human melanocytes, 198 genes out of »9000 arrayed were found modulated > 1.9 times following artificial ultraviolet (mainly ultraviolet-B) irradiation (100 mJ per cm2).

ORGANISM(S): Homo sapiens

SUBMITTER: Keith Hoek

PROVIDER: E-GEOD-9016 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification by cDNA microarray technology of genes modulated by artificial ultraviolet radiation in normal human melanocytes: relation to melanocarcinogenesis.

Valéry C C Grob J J JJ Verrando P P

The Journal of investigative dermatology 20011201 6

Target genes of ultraviolet stress response in cutaneous melanocytes, potentially associated with solar-induced melanocarcinogenesis, were characterized by cDNA microarray technology. In cultured normal human melanocytes, 198 genes out of approximately 9000 arrayed were found modulated > or = 1.9 times following artificial ultraviolet minus sign mainly ultraviolet-B minus sign irradiation (100 mJ per cm(2)). Among them, 159 corresponded to known sequences, the encoded proteins being mostly invol ...[more]

PMID: 11886511

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