Unknown,Transcriptomics,Genomics,Proteomics

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Chordoma_32k_1Mb


ABSTRACT: Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridization DNA copy number analysis of 21 fresh frozen chordoma biopsies, and the respective relapse in four of them, using 32k and 1Mb array CGH. All cases showed copy number alterations and primarily deletions of chromosomal regions were found. Particularly, the CDKN2A and CDKN2B loci in 9p21 were homo- or heterozygously lost in 70% of the tumors. Cases 1-11 were analyzed using 32k array CGH and male genomic DNA (Promega) was used as reference. Cases 17-26, and the respective relapse in four of these tumors, were analyzed with 1 Mb array CGH, using sex matched controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Karolin Hallor 

PROVIDER: E-GEOD-9023 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation.

Hallor K H KH   Staaf J J   Jönsson G G   Heidenblad M M   Vult von Steyern F F   Bauer H C F HC   Ijszenga M M   Hogendoorn P C W PC   Mandahl N N   Szuhai K K   Mertens F F  

British journal of cancer 20071211 2


The initiating somatic genetic events in chordoma development have not yet been identified. Most cytogenetically investigated chordomas have displayed near-diploid or moderately hypodiploid karyotypes, with several numerical and structural rearrangements. However, no consistent structural chromosome aberration has been reported. This is the first array-based study characterising DNA copy number changes in chordoma. Array comparative genomic hybridisation (aCGH) identified copy number alterations  ...[more]

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