Unknown,Transcriptomics,Genomics,Proteomics

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LmrR Lactococcus lactis MG1363


ABSTRACT: Comparison of L. lactis NZ9000 ?lmrR versus L. lactis NZ9000 wild type Keywords: Transcription profiling Comparison between strain lacking transcriptional regulator LmrR of major Lactococcal mdr transporter LmrCD, and wild type parental strain.

ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363

SUBMITTER: Anne Jong 

PROVIDER: E-GEOD-9168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis.

Agustiandari Herfita H   Lubelski Jacek J   van den Berg van Saparoea H Bart HB   Kuipers Oscar P OP   Driessen Arnold J M AJ  

Journal of bacteriology 20071109 2


LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a DeltalmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression. ...[more]

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