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Unknown,Transcriptomics,Genomics,Proteomics

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SUS1

ABSTRACT: Transcriptome analysis of sus1 mutant in reference to its parental wild type reference. Iterative global median method was used for between sample normalization. z-test was performed to evaluate differential gene expression.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Oreto Antunez

PROVIDER: E-GEOD-920 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery.

Rodríguez-Navarro Susana S Fischer Tamás T Luo Ming-Juan MJ Antúnez Oreto O Brettschneider Susanne S Lechner Johannes J Pérez-Ortín Jose E JE Reed Robin R Hurt Ed E

Cell 20040101 1

Gene expression is a coordinated multistep process that begins with transcription and RNA processing in the nucleus followed by mRNA export to the cytoplasm for translation. Here we report the identification of a protein, Sus1, which functions in both transcription and mRNA export. Sus1 is a nuclear protein with a concentration at the nuclear pores. Biochemical analyses show that Sus1 interacts with SAGA, a large intranuclear histone acetylase complex involved in transcription initiation, and wi ...[more]

PMID: 14718168

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