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Transcription profiling of different regions of E16.5 mouse cerebral cortex to identify region- and layer-specific genes.

ABSTRACT: The mammalian neocortex develops layer organizations with regional differences represented by expression of multiple genes at embryonic stages. These genes could play important roles in the formation of areal cyto-architecture, yet, the number of genes identified so far is not sufficient to explain such intricate processes. Here we collected five regions; the medial, dorsal, lateral, rostral, and occipital, from the dissected E16.5 mouse cerebral cortex and performed extensive gene expression analysis using the Affymetrix U74Av2 array. Keywords = mouse Keywords = cortex Keywords = development Keywords = regional Keywords = gene expression Keywords = medial Keywords = dorsal Keywords = lateral Keywords = rostral Keywords = occipital

ORGANISM(S): Mus musculus

SUBMITTER: Nobuo Funatsu

PROVIDER: E-GEOD-929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes.

Funatsu Nobuo N Inoue Takayoshi T Nakamura Shun S

Cerebral cortex (New York, N.Y. : 1991) 20040513 9

The mammalian neocortex develops layer organizations with regional differences represented by expression of multiple genes at embryonic stages. These genes could play important roles in the formation of areal cyto-architecture, yet, the number of genes identified so far is not sufficient to explain such intricate processes. Here we collected five regions--the medial, dorsal, lateral, rostral and occipital--from the dissected E16.5 mouse cerebral cortex and performed extensive gene expression ana ...[more]

PMID: 15142957

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Project description:The mammalian neocortex develops layer organizations with regional differences represented by expression of multiple genes at embryonic stages. These genes could play important roles in the formation of areal cyto-architecture, yet, the number of genes identified so far is not sufficient to explain such intricate processes. Here we collected five regions; the medial, dorsal, lateral, rostral, and occipital, from the dissected E16.5 mouse cerebral cortex and performed extensive gene expression analysis using the Affymetrix U74Av2 array. Keywords = mouse Keywords = cortex Keywords = development Keywords = regional Keywords = gene expression Keywords = medial Keywords = dorsal Keywords = lateral Keywords = rostral Keywords = occipital Keywords: ordered

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