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Transcription profiling of human hematopoietic cells from 38 healthy donors and leukemic blasts from 26 AML patients

ABSTRACT: Acute myeloid leukemia (AML) is one of the most common and deadly forms of hematopoietic malignancies. We hypothesized that microarray studies could identify previously unrecognized expression changes that only occur only in AML blasts. We were particularly interested in those genes with increased expression in AML, believing that these genes may be potential therapeutic targets. Experiment Overall Design: We compared gene expression profiles between normal hematopoietic cells from 38 healthy donors and leukemic blasts from 26 AML patients. Normal hematopoietic samples included CD34+ selected cells (N = 18), unselected bone marrows (N = 10), and unselected peripheral bloods (N = 10).

ORGANISM(S): Homo sapiens

SUBMITTER: Derek Stirewalt

PROVIDER: E-GEOD-9476 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of genes with abnormal expression changes in acute myeloid leukemia.

Stirewalt Derek L DL Meshinchi Soheil S Kopecky Kenneth J KJ Fan Wenhong W Pogosova-Agadjanyan Era L EL Engel Julia H JH Cronk Michelle R MR Dorcy Kathleen Shannon KS McQuary Amy R AR Hockenbery David D Wood Brent B Heimfeld Shelly S Radich Jerald P JP

Genes, chromosomes & cancer 20080101 1

Acute myeloid leukemia (AML) is one of the most common and deadly forms of hematopoietic malignancies. We hypothesized that microarray studies could identify previously unrecognized expression changes that occur only in AML blasts. We were particularly interested in those genes with increased expression in AML, believing that these genes may be potential therapeutic targets. To test this hypothesis, we compared gene expression profiles between normal hematopoietic cells from 38 healthy donors an ...[more]

PMID: 17910043

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Aberrant expressed genes in AML

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Expression data from human AML blasts and healthy CD34+ bone marrow cells

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