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Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma

ABSTRACT: Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; cetuximab, a monoclonal antibody (mAb) against Epidermal Growth Factor Receptor (EGFR), and AMG 479, a mAb against Insulin-like Growth Factor-1 Receptor (IGF-1R). In tumor tissue of this patient we observed gene expression modulation by cetuximab and AMG 479 suggesting crosstalk between the EGFR and IGF-1R pathways that may have sensitized the tumor to MTX. This represents a promising novel approach to development of targeted agents in refractory cancer. Keywords: tumor response 10 samples from different time points during course of treatment in a single individual.

ORGANISM(S): Homo sapiens

SUBMITTER: Christine Chung 

PROVIDER: E-GEOD-9600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma.

Chung Christine H CH   Pohlmann Paula R PR   Rothenberg Mace L ML   Burkey Brian B BB   Parker Joel J   Palka Kevin K   Aulino Joseph J   Puzanov Igor I   Murphy Barbara B  

Head & neck 20100722 12

<h4>Background</h4>Recurrent head and neck squamous cell carcinoma (HNSCC) remains a difficult cancer to treat. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents, cetuximab, and AMG-479 (monoclonal antibody against insulin-like growth factor-1 receptor [IGF-1R]).<h4>Methods</h4>The clinical information was collected by a retrospective medical record review under an Institutional Review Board-approved protocol. Fr  ...[more]

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