Transcription profiling of mouse naive, effector, memory and exhausted virus-specific CD8 T cells after chronic viral infection
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ABSTRACT: CD8 T cells normally differentiate from resting naïve T cells into function effector and then memory CD8 T cells following acute infections. During chronic viral infections, however, virus-specific CD8 T cells often become exhausted. We used microarrays to examine the gene expression differences between naive, effector, memory and exhausted virus-specific CD8 T cells following lymphocytic choriomeningitis virus infection. Experiment Overall Design: Three or four independent samples were sorted by flow cytometry for each cell type (naive, effector, memory and exhausted) virus-specific CD8 T cells. RNA was extracted and hybridized to Affymetrix microarrays.
ORGANISM(S): Mus musculus
SUBMITTER: Shruti Subramaniam
PROVIDER: E-GEOD-9650 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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