Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of human Waldenstroms macroglobulinemia CD19+ WM B cells (WM-BC) and CD138+ WM plasma cells (WM-PC) with those of normal CD19+ peripheral blood B cells (PB-BC), tonsil-BC (T-BC), CD138+ T-PC and bone marrow PC (N-PC) reveals biological insights into its pathophysiology


ABSTRACT: Waldenströms macroglobulinemia (WM) is a rare lymphoproliferative disorder with apparent morphologic and immunophenotypic heterogeneity and its origins are still poorly understood. In this study, using Gene-Expression Profiling (GEP), we compared the global mRNA expression patterns of CD19+ WM B cells (WM-BC) and CD138+ WM plasma cells (WM-PC) with those of normal CD19+ peripheral blood B cells (PB-BC), tonsil-BC (T-BC), CD138+ T-PC and bone marrow PC (N-PC). Experiment Overall Design: The sample cohort studied consisted of CD19-selected peripheral blood B cells (PB-BC; n = 7), tonsil B cells (T-BC; n = 7), bone marrow B cells from WM (WM-BC; n = 12), tonsil plasma cells (T-PC; n = 9), bone marrow plasma cells from healthy donors (N-PC; n = 10), WM plasma cells (WM-PC, n = 9), and MM plasma cells (MM-PC; n = 11).

ORGANISM(S): Homo sapiens

SUBMITTER: Fenghuang Zhan 

PROVIDER: E-GEOD-9656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2012-10-01 | GSE9656 | GEO
2024-02-28 | GSE235723 | GEO
2020-05-13 | GSE139671 | GEO
2007-03-01 | E-GEOD-6691 | biostudies-arrayexpress
2007-03-01 | GSE6691 | GEO
| PRJNA725593 | ENA
| PRJNA259513 | ENA
| PRJNA940585 | ENA
2012-08-09 | E-GEOD-31350 | biostudies-arrayexpress
2021-10-20 | GSE157042 | GEO