Transcription profiling of mouse embryos exposed to diabetes reveals maternal diabetes alters transcriptional programs in the developing embryo

ABSTRACT: Diabetic embryopathy can affect any developing organ system, although cardiovascular malformations, neural tube defects and caudal dysgenesis syndrome are the most prominent congenital malformations. We hypothesize that the metabolic imbalance occurring in diabetic pregnancy de-regulates tissue specific gene expression programs in the developing embryo. In order to identify genes whose expression is affected by maternal diabetes, we analyzed gene expression profiles of diabetes-exposed mouse embryos by using Affymetrix microarrays. We identified 129 genes with altered expression levels; 21 genes had increased and 108 genes had decreased expression levels in diabetes-exposed embryos relative to controls. A substantial fraction of these genes (35) are essential for normal embryonic developme

ORGANISM(S): Mus musculus

SUBMITTER: Gabriela Pavlinkova 

PROVIDER: E-GEOD-9675 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress