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Transcription profiling of newborn mice infected with Shigella flexneri

ABSTRACT: In order to identify the developmental changes controlling the switch from disease susceptibility to resistance, we performed global gene expression analysis on non-infected and infected intestinal tissues taken from 4-day- and 7-day-old animals. Experiment Overall Design: RNA from intestinal tissues of 4-day- or 7-day-old mice infected or not with invasive (INV+) or non-invasive (INV-) Shigella strains during 2 or 4 hours were hybridized on Murine MOE430A Affymetrix Genechip.

ORGANISM(S): Mus musculus

SUBMITTER: Thierry Pedron

PROVIDER: E-GEOD-9785 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Maturation of paneth cells induces the refractory state of newborn mice to Shigella infection.

Fernandez Maria-Isabel MI Regnault Béatrice B Mulet Céline C Tanguy Myriam M Jay Philippe P Sansonetti Philippe J PJ Pédron Thierry T

Journal of immunology (Baltimore, Md. : 1950) 20080401 7

The intestinal tract of adult mice is naturally resistant to infection by Shigella, the causative agent of bacillary dysentery in humans. Conversely, newborn mice are highly susceptible to intragastric Shigella infection and develop inflammatory lesions of the jejunal mucosa, very similar to those observed in the colon of dysenteric patients. However, the susceptibility period is short and one week after birth, animals have acquired a status of resistance characteristic of adult animals. To iden ...[more]

PMID: 18354217

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