Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Thierry Pedron
PROVIDER: E-GEOD-9785 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Journal of immunology (Baltimore, Md. : 1950) 20080401 7
The intestinal tract of adult mice is naturally resistant to infection by Shigella, the causative agent of bacillary dysentery in humans. Conversely, newborn mice are highly susceptible to intragastric Shigella infection and develop inflammatory lesions of the jejunal mucosa, very similar to those observed in the colon of dysenteric patients. However, the susceptibility period is short and one week after birth, animals have acquired a status of resistance characteristic of adult animals. To iden ...[more]