Ontology highlight
ABSTRACT:
ORGANISM(S): Pseudomonas aeruginosa
SUBMITTER: George O'Toole
PROVIDER: E-GEOD-9991 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Anderson Gregory G GG Moreau-Marquis Sophie S Stanton Bruce A BA O'Toole George A GA
Infection and immunity 20080122 4
P. aeruginosa forms biofilms in the lungs of individuals with cystic fibrosis (CF); however, there have been no effective model systems for studying biofilm formation in the CF lung. We have developed a tissue culture system for growth of P. aeruginosa biofilms on CF-derived human airway cells that promotes the formation of highly antibiotic-resistant microcolonies, which produce an extracellular polysaccharide matrix and require the known abiotic biofilm formation genes flgK and pilB. Treatment ...[more]