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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of karp under hypoxic conditions

ABSTRACT:

ORGANISM(S): Carpus carpio

SUBMITTER: Jane Fraser

PROVIDER: E-MAXD-10 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hypoxia-inducible myoglobin expression in nonmuscle tissues.

Fraser Jane J de Mello Luciane Vieira LV Ward Deborah D Rees Huw H HH Williams Daryl R DR Fang Yongxiang Y Brass Andrew A Gracey Andrew Y AY Cossins Andrew R AR

Proceedings of the National Academy of Sciences of the United States of America 20060209 8

Myoglobin (Myg) is an oxygen-binding hemoprotein that is widely thought to be expressed exclusively in oxidative skeletal and cardiac myocytes, where it plays a key role in coping with chronic hypoxia. We now show in a hypoxia-tolerant fish model, that Myg is also expressed in a range of other tissues, including liver, gill, and brain. Moreover, expression of Myg transcript was substantially enhanced during chronic hypoxia, the fold-change induction being far greater in liver than muscle. By usi ...[more]

PMID: 16469844

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